Berrazueta and colleageus (1996) first used transdermal nitroglycerine has been previously used for treating shoulder tendinopathy. In muscle cells of blood vessels, nitroglycerine (NT) transforms into nitric oxide. Nitric oxide has been shown to play a role in tendon repair by enhancing fibroblast regeneration and vasodilation (Murrell 2007).
One prospective controlled trial found transdermal NT patch was effective in improving pain intensity and functional movements among people with shoulder tendinopathy post SCI. Safety of the treatment is yet to be assessed.
There is level 2 evidence (from one prospective controlled trial: Giner-Pascual et al. 2011) that Transdermal Nitroglycerine reduces post-SCI shoulder tendinopathy pain.