Histomorphometry are measurements from bone biopsies to provide an in-depth understanding of bone. There are two types of bone histomorphometry, dynamic and static. Dynamic histomorphometry involves using substances such as tetracycline to measure tissue growth. Static histomorphometry involves determining the size and types of cells; measurements include length, area or cell counts.

Although bone histomorphometry is considered a valuable tool, it is not always feasible because it requires surgically obtaining bone specimens from consenting participants. As biomarker technology continues to improve, the use of histomorphometry in live human subjects will likely be supplanted by this less invasive testing modality.