How a wheelchair is used is examined from different perspectives. Various factors are explored in relation to how they influence how wheelchairs are used, ultimately to increase participation and quality of life. The research literature in this area is broad based, diverse, often overlapping and primarily focuses on manual wheelchair use. The first subsection explores the characteristics of wheelchair use in daily life. The second subsection focuses on participants’ satisfaction with their wheelchair and its performance. The third subsection expands on the satisfaction but from the perspective of how repairs, accidents, falls and these potential adverse consequences affect wheelchair use. The final section related to wheelchair use is that of wheelchair skills.