Prostaglandin E2 is a group of hormone-like substances that contribute to a wide range of body functions including the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels and control of blood pressure.
Prostaglandin E2 is a group of hormone-like substances that contribute to a wide range of body functions including the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels and control of blood pressure.
| Author Year; Country Score Research Design Total Sample Size | Methods | Outcome |
| Frankel & Mathias 1980; UK Prospective controlled trial N=5 | Population: 5 patients with complete SCI; age range: 25-37 years; level of injury: C5-T4, 5-108 months post-injury. Treatment: trans-rectal electrical ejaculation with and without intravenous administration of Prostaglandin E2. Outcome Measures: heart rate, blood pressure, electrocardiogram. | 1. Resting BP decreased and resting HR increased with Prostaglandin E2. 2. BP decreased during electrical stimulation, which enabled tolerance of more intense stimulation and successful ejaculation in 2 patients.
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Frankel and Mathias (1980) studied five subjects; 3 subjects underwent administration with and without Prostaglandin E2 and showed that the level of BP recorded during electrical ejaculation decreased with the drug.