Prostaglandin E2
Prostaglandin E2 is a group of hormone-like substances that contribute to a wide range of body functions including the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels and control of blood pressure.
| Author Year; Country Score Research Design Total Sample Size |
Methods | Outcome |
|
Frankel & Mathias 1980; UK |
Population: 5 patients with complete SCI; age range: 25-37 years; level of injury: C5-T4, 5-108 months post-injury. Treatment: trans-rectal electrical ejaculation with and without intravenous administration of Prostaglandin E2. Outcome Measures: heart rate, blood pressure, electrocardiogram. |
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Discussion
Frankel and Mathias (1980) studied five subjects. Three subjects underwent administration with and without Prostaglandin E2 and showed that the level of BP recorded during electrical ejaculation decreased with the drug.
Conclusion
There is level 2 evidence from a very small prospective controlled study (Frankel & Mathias 1980) which used subjects as their own controls and showed that the level of BP recorded during electrical ejaculation was substantially reduced with Prostaglandin E2.
