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Autonomic Dysreflexia

Prostaglandin E2

Prostaglandin E2 is a group of hormone-like substances that contribute to a wide range of body functions including the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels and control of blood pressure.

Author Year; Country
Research Design
Total Sample Size
Methods Outcome

Frankel & Mathias 1980; UK
Prospective controlled trial

Population: 5 patients with complete SCI; age range: 25-37 years; level of injury: C5-T4, 5-108 months post-injury.
Treatment: trans-rectal electrical ejaculation with and without intravenous administration of Prostaglandin E2.
Outcome Measures: heart rate, blood pressure, electrocardiogram.
  1. Resting BP decreased and resting HR increased with Prostaglandin E2.
  2. BP decreased during electrical stimulation, which enabled tolerance of more intense stimulation and successful ejaculation in 2 patients.


Frankel and Mathias (1980) studied five subjects. Three subjects underwent administration with and without Prostaglandin E2 and showed that the level of BP recorded during electrical ejaculation decreased with the drug.


There is level 2 evidence from a very small prospective controlled study (Frankel & Mathias 1980) which used subjects as their own controls and showed that the level of BP recorded during electrical ejaculation was substantially reduced with Prostaglandin E2.

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