Prostaglandin E2
Prostaglandin E2 is a group of hormone-like substances that contribute to a wide range of bodily functions including the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, and the control of blood pressure.
Discussion
Frankel and Mathias (1980) studied five individuals; 3 participants underwent administration with and without Prostaglandin E2 and showed that the level of BP recorded during electrical ejaculation decreased with the drug.
Conclusion
There is level 2 evidence (from one prospective controlled study) (Frankel & Mathias 1980) which used participants as their own controls and showed that the level of BP recorded during electrical ejaculation was substantially reduced with Prostaglandin E2.