Prostaglandin E2

Prostaglandin E₂ is a naturally occurring, hormone-like substance that helps regulate blood vessel tone, smooth muscle activity, and blood pressure. For managing autonomic dysreflexia, Prostaglandin E₂ can be used pharmacologically to help control hypertensive episodes by promoting vascular relaxation and supporting blood pressure stability.

Discussion

Frankel and Mathias (1980) studied five individuals; 3 participants underwent administration with and without Prostaglandin E2 and showed that the level of BP recorded during electrical ejaculation decreased with the drug.

Conclusion

There is level 2 evidence (from one prospective controlled study) (Frankel & Mathias 1980) which used participants as their own controls and showed that the level of BP recorded during electrical ejaculation was substantially reduced with Prostaglandin E2.