Prostaglandin E2

Prostaglandin E2 is a group of hormone-like substances that contribute to a wide range of body functions including the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels and control of blood pressure.

Discussion

Frankel and Mathias (1980) studied five subjects. Three subjects underwent administration with and without Prostaglandin E2 and showed that the level of BP recorded during electrical ejaculation decreased with the drug.

Conclusion

There is level 2 evidence from a very small prospective controlled study (Frankel & Mathias 1980) which used subjects as their own controls and showed that the level of BP recorded during electrical ejaculation was substantially reduced with Prostaglandin E2.