Mesenchymal Stem Cells Transplantation Therapy

Bone marrow mesenchymal stem cells (BMSCs) are highly proliferating and self-renewing cells. Transplantation of BMSCs may be an effective treatment for nerve injury reconstruction or regeneration in patients with SCI. (Assinck et al. 2017)

Discussion

One RCT evaluated the effectiveness of standard rehabilitation or standard rehabilitation with BMSC transplantation among patients admitted to the hospital. The study found that among those that received both standard rehabilitation and BMSC transplantation, there was a significant reduction in anxiety symptoms compared to the rehabilitation only group.

Conclusion

There is level 1b evidence from one RCT that mesenchymal stromal cells combined with standard SCI rehabilitation is effective at reducing symptoms of anxiety compared to SCI rehabilitation alone.