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Effect of Medications Other Than Baclofen on Spasticity after SCI

Although baclofen is the most widely used drug for the treatment of spasticity in SCI, other drugs used as anti-spasmodics include tizanidine, cyproheptadine, diazepam, gabapentin, L-threonine, cannabis, dantrolene, clonidine (oral, transdermal and intrathecal), 4-aminopyridine (intravenous, intrathecal, immediate and sustained release) and others that will each be discussed briefly.