AA

Other Pharmaceuticals

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There are many other medications with potential benefit for the treatment of pulmonary function in SCI. The use of anticoagulants for the prevention of deep vein thrombosis and pulmonary emboli is covered in Chapter 15.  Other medications used in the treatment of asthma and/or chronic obstructive pulmonary disease such as cromolyn sodium, methylxanthines and inhaled corticosteroids have not been studied in SCI.

Table 7: Other Pharmaceuticals

Discussion

Ambroxol is a mucolytic medication that is used in the treatment of respiratory diseases associated with excessive mucus. There is one RCT (Li et al. 2012) that shows that high-dose IV ambroxol after surgical cervical spinal cord decompression and stabilization reduces the rate of postoperative pneumonia and increases blood oxygenation.

Conclusion

There is level 1b evidence (based on 1 RCT) (Li et al. 2012) that high-dose IV ambroxol after surgery increases blood oxygenation in cervical spinal cord injured patients with motor complete injuries.