Pointillart et al. (2000) did not find any significant differences in terms of neurological recovery among individuals receiving MP, nimodipine, MP plus nimodipine, or no treatment.Animal studies have shown that nimodipine on its own may not be beneficial for treating SCI (Faden et al. 1984a; Ford & Malm, 1985), but when used in combination with other agents, such as adrenaline, there were significant effects on enhancing spinal cord blood flow (Ross & Tator, 1991). Larger, randomized clinical trials are necessary to determine the effectiveness of nimodipine on neurological recovery in acute SCI.
There is level 1b evidence (from one RCT; Pointillart et al. 2000) that nimodipine is not effective in promoting neurological recovery in acute SCI individuals.
Nimodipine is not effective for neurological recovery during the acute phase post SCI.