Table 11 Cell Therapy Interventions for Reducing Spasticity

Author Year

Country
Research Design

Score
Total Sample Size

Methods Outcome

Vaquero et al. 2018

Spain

Pre-Post

NInitial=11

NFinal=9

 

Population: SCI (n=11): Mean age=44.91±10.17yr; Gender: males=7, females=4; Level of injury: C=4, T=4, TL=3; Mean time since injury=13.65±14.79yr; AIS scale: A=3, B= 4, C=3, D=1.

Intervention: All participants received autologous mesenchymal stromal cell (MSC) therapy consisting of 3 intrathecal administrations of 100 x 106 MSCs. Administrations consisted of subarachnoid administration by lumbar puncture Outcomes were measured at baseline, and at 4, 7, and 10 month follow ups.   

Outcome Measures: Ashworth Scale (AS); Penn Scale (PS).

1.     While there was a decrease in AS and PS post intervention, statistical significance was not achieved for any of the follow up time points (p>0.05 for all).
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