Pressure Ulcers Table 15 Topical Negative Pressure Therapy for Pressure Ulcer Healing Post SCI

Author Year
Research Design
Total Sample Size



De Laat et al. 2011

Population: Patients >18 yr who were admitted to the study hospital with difficult-to-heal surgical wounds, or paraplegic and tetraplegia patients with pressure ulcers grade IV according to the European Pressure Ulcer Advisory Panel grading system 19.
Intervention: Topical negative pressure therapy or treatment with conventional dressing therapy with sodium hypochlorite
Outcome Measures: 50% wound volume reduction, with a maximum follow-up time of 6 wk, measuring the difference between the weekly measured wound volume and the initial wound volume before treatment.

  1. Topical negative pressure resulted in almost 2 times faster wound healing than treatment with sodium hypochlorite, and is safe to use in patients with difficult-to-heal wounds.

Ho et al.2010

Population: SCI inpatients with Stage III/IV pelvic pressure ulcer.
Intervention: Standard wound care with NPWT versus standard wound care alone (NoNPWT).
Outcome Measures: Change in wound surface area (WSA) using the Verg Videometer Measurement Documentation software.

  1. In SCI patients with Stage III/IV pelvic pressure ulcers, NPWT did not significantly influence the rate of healing.
  2. Healing outcomes in the NPWT group were significantly influenced by albu
  3. Nutritional status appears to be important in the effectiveness of NPWT.min levels.

Coggrave et al. 2002

Population: Mean age=44.4 yr; Gender: males=5, females=2; Level of injury: paraplegia=4, tetraplegia=3; Location of pressure ulcer: trochanter=3, sacrum=4; Stage of ulcer: IV=6.
Intervention: Topical negative pressure (TNP) applied continuously (125 mmHg), dressing changed every 4-7 days. All patients seen and assessed by dietitian; nursed on a pressure redistribution surface; turned frequently; wound debrided as necessary pre-treatment.
Outcome Measures: Picture and wound swabs (every dressing change); Pressure ulcer volume (beginning and end of treatment).

  1. Within 1-2 days of treatment initiation, granulation tissue developed in all wounds.
  2. Wound volume and grade decreased (33-96%) in all subjects, but rate and extent varied. Bacterial colonization was also reduced in each wound.
  3. Limited dressing problems were described, although rashes and pain were reported in some.
  4. Seal preservation in certain areas, overlapping foam on healthy skin and pressure application on bony protrusions, were reported as practical problems.