Nutrition Table 12 Responses to Dietary Sodium Restriction in Persons Post SCI

Author Year;
PEDro Score
Research Design
Sample Size



Sutters et al. 1992;
Case control

Population: Mean age=28 yr; Gender: males=15, females=0; Level of injury: paraplegia=6, tetraplegia=9; Time since injury=2 mo-1 yr.
Treatment: All individuals received a sodium restriction diet (SRD) over 5 days consisting of 90 g protein, 90 mmol potassium, and 300 g carbohydrates. Sodium intake was 260 mmol/day for days 1-3 but was reduced to 20 mmol/day on day 4 and 5.
Outcome Measures:Total and fractional urinary sodium excretion, mean arterial pressure, creatinine clearance, plasma renin activity and atrial natriuretic peptide (ANP) concentration compared between those with tetraplegia (dissociated sympathetic control, DSC) and paraplegia (intact sympathetic control, ISC).

  1. Total and fractional urinary sodium excretion fell in response to sodium restriction in both groups, but the fall in fractional sodium excretion was greater in the DSC group compared to ISC group.
  2. Supine mean arterial pressure fell during the low salt period in the DSC group but was unaffected by salt restriction in the IS group.
  3. In the DS group, creatinine clearance remained constant throughout the low salt period but fell during salt restriction in the ISC group.
  4. Plasma renin activity was lower during salt loading in DSC subjects but increased more rapidly and to higher levels in response to salt restriction.
  5. Plasma atrial natriuretic peptide concentration was higher in the DSC group during salt loading and salt restriction.