Bracken et al. (1990)
Population: Age range=13-34 yr; Gender: not specified; Level of injury: not specified; Severity of injury: complete= 60%, incomplete=40%.
Treatment: Patients were randomized to receive either naloxone (25 mg/mL), methylprednisolone (MP; 62.5 mg/mL) or placebo. Both drugs were administered as a 15 minute loading dose followed by a 23 hr maintenance dose.
Outcome Measures:The following after 6 weeks and 6 months: motor function, sensory function (pinprick and light touch), adverse event outcomes.
Chronicity: Individuals were randomized to study groups within 12 hr of sustaining injury.