Impaired nutritional status and decreased nutritional intake are common in those with SCI and significantly associated with development and timely healing of pressure ulcers (Consortium for Spinal Cord Medicine 2000; Houghton et al. 2013). Spungen et al. (2001) stated that use of anabolic steroids and increased protein intake have been associated with promoting anabolism, weight gain and in turn wound closure in burn patients. The United Stated Food and Drug Administration approved oxandrolone for the treatment of involuntary weight loss and for chronic infections. Since a “hypermetabolic, potentially catabolic state also is associated with pressure ulcers” (Spungen et al. 2001, p. 140), the use of an anabolic steroid agent may also promote closure of nonhealing, pressure ulcers in the SCI population.
In a case series of nine subjects with stage III and IV pressure ulcers, Spungen et al. (2001) demonstrated complete healing in the majority of subjects (8/9), 3-12 months after daily administration of 20mg of oxandrolone. Bauman et al. (2013; N=212) initiated a RCT in a similar patient group suffering from stage III and IV pressure ulcers. Unfortunately, this ambitious study was terminated early due to feasibility issues. The most significant of these issues included the heterogeneity of confounding co-morbidities across the study cohort, non-uniformity of clinical care across contributing sites, and high withdrawal rates in both groups likely due to the propensity of people with SCI to develop complications independent of the study. Available results did not show improvement in wound healing or closure between the active and control groups. The results did, however, reveal markedly increased serum pre-albumin levels that reflected improved better nutritional status in general. Ultimately, this RCT did not produce results to support that oxandrolone was more useful than placebo to improve chronic pressure ulcer healing.
There is level 2 evidence (from one flawed randomized controlled trial; Bauman et al. 2013) that does not support the use of oxandrolone (anabolic steroid) to facilitate healing of serious pressure ulcers post SCI. However, very limited, earlier level 4 evidence (from one case series; Spungen et al. 2001) did lend some support for the use of oxandrolone to promote healing of stage III and IV pressure ulcers post SCI.
- The anabolic steroid agent Oxandrolone does not promote healing of serious pressure ulcers post SCI.