AA

Prazosin (Minipress)

Download as a PDF

Prazosin, a postsynaptic alpha-1 adrenoceptor blocker, lowers blood pressure by relaxing blood vessels. Prazosin has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. The recommended starting dose in adults is 0.5 or 1 milligram (mg) taken two or three times a day.

Table 17: Prazosin (Minipress)

Discussion

In a small (n=15) (Krum et al. 1992), but high quality RCT, Prazosin twice daily was well tolerated and did not affect the baseline blood pressure; AD episodes were also less severe and shorter in duration over a 2 week period.

Conclusion

  • There is level 1 evidence (from one RCT) (Krum et al. 1992), that Prazosin is superior to placebo in the prophylactic management of AD.
  • Prazosin can prophylactically reduce severity and duration of AD episodes in SCI.